Editing A-Series (section)

== Biological basis ==

Routine A-Series production did not use donor egg cells. Cultured Alexandru-derived cells were reprogrammed into a totipotent-like state and then assembled into a synthetic embryo. The reset retained Alexandru's genome while changing the regulatory state that limited mature cells to a particular tissue. Descendants of the reprogrammed population produced the developing body and its temporary supporting tissue.

Rambam introduced the accelerated developmental program before embryo assembly. Rapid mitosis expanded cell numbers, but viable development also required each lineage to begin the correct gene-expression program at the correct time. Unequal maturation between tissues could allow the body to keep growing while an organ or part of the skeleton remained behind. Severe desynchronization produced deformity or structural weakness.